European Journal of Vascular & Endovascular Surgery
Volume 34, Issue 4 , Pages 483-488 , October 2007

Hereditary Thrombophilia and Venous Thromboembolism: Critical Evaluation of the Clinical Implications of Screening

  • L. Mazzolai

      Affiliations

    • Service of Angiology, Department of Medicine, CHUV, Lausanne University Hospital, Lausanne, Switzerland
    • Corresponding Author InformationCorresponding author. L. Mazzolai, Service of Angiology, Lausanne University Medical School, CHUV, Av Pierre Decker 7, 1011 Lausanne, Switzerland.
    • ,
  • M.A. Duchosal

      Affiliations

    • Service of Hematology, Department of Medicine, CHUV, Lausanne University Hospital, Lausanne, Switzerland

,Accepted 25 April 2007.

References 

  1. Gray HW. The natural history of venous thromboembolism: impact on ventilation/perfusion scan reporting. Semin Nucl Med. 2002 July;32(3):159–172
  2. Anderson FA, Wheeler HB, Goldberg RJ, Hosmer DW, Patwardhan NA, Jovanovic B, et al. A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study. Arch Intern Med. 1991 May;151(5):933–938
  3. Silverstein MD, Heit JA, Mohr DN, Petterson TM, O'Fallon WM, Melton LJ. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med. 1998 March 23;158(6):585–593
  4. van der Meer FJ, Koster T, Vandenbroucke JP, Briet E, Rosendaal FR. The Leiden Thrombophilia Study (LETS). Thromb Haemost. 1997 August;78(1):631–635
  5. Cushman M, Tsai AW, White RH, Heckbert SR, Rosamond WD, Enright P, et al. Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology. Am J Med. 2004 July 1;117(1):19–25
  6. Cushman M. Inherited risk factors for venous thrombosis. Hematology Am Soc Hematol Educ Program. 2005;452–457
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  8. Baglin T, Luddington R, Brown K, Baglin C. Incidence of recurrent venous thromboembolism in relation to clinical and thrombophilic risk factors: prospective cohort study. Lancet. 2003 August 16;362(9383):523–526
  9. The PROCARE group. Is recurrent venous thromboembolism more frequent in homozygous patients for the factor V Leiden mutation than in heterozygous patients?. Blood Coagul Fibrinolysis. 2003 September;14(6):523–529
  10. Vossen CY, Walker ID, Svensson P, Souto JC, Scharrer I, Preston FE, et al. Recurrence rate after a first venous thrombosis in patients with familial thrombophilia. Arterioscler Thromb Vasc Biol. 2005 September;25(9):1992–1997
  11. Geerts WH, Pineo GF, Heit JA, Bergqvist D, Lassen MR, Colwell CW, et al. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004 September;126(Suppl. 3):338S–400S
  12. Vossen CY, Conard J, Fontcuberta J, Makris M, van der Meer FJ, Pabinger I, et al. Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT). J Thromb Haemost. 2005 March;3(3):459–464
  13. van der Meer FJ, Rosendaal FR, Vandenbroucke JP, Briet E. Bleeding complications in oral anticoagulant therapy. An analysis of risk factors. Arch Intern Med. 1993 July 12;153(13):1557–1562
  14. Palareti G, Leali N, Coccheri S, Poggi M, Manotti C, D'Angelo A, et al. Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT). Italian Study on Complications of Oral Anticoagulant Therapy. Lancet. 1996 August 17;348(9025):423–428
  15. Machin SJ. Pros and cons of thrombophilia testing: cons. J Thromb Haemost. 2003 March;1(3):412–413
  16. Somma J, Sussman , Rand JH. An evaluation of thrombophilia screening in an urban tertiary care medical center: a “real world” experience. Am J Clin Pathol. 2006 July;126(1):120–127

PII: S1078-5884(07)00328-0

doi: 10.1016/j.ejvs.2007.04.023

European Journal of Vascular & Endovascular Surgery
Volume 34, Issue 4 , Pages 483-488 , October 2007

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