European Journal of Vascular & Endovascular Surgery
Volume 35, Issue 2 , Pages 153-158 , February 2008

Periodontitis May Increase the Risk of Peripheral Arterial Disease

  • Y.-W. Chen

      Affiliations

    • Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University
    • Center of Excellence (COE), Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University
    • Corresponding Author InformationCorresponding author. Y.-W. Chen, Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.
    • ,
  • M. Umeda

      Affiliations

    • Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University
    • ,
  • T. Nagasawa

      Affiliations

    • Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University
    • ,
  • Y. Takeuchi

      Affiliations

    • Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University
    • ,
  • Y. Huang

      Affiliations

    • Department of Vascular and Applied Surgery, Graduate School, Tokyo Medical and Dental University
    • ,
  • Y. Inoue

      Affiliations

    • Department of Vascular and Applied Surgery, Graduate School, Tokyo Medical and Dental University
    • ,
  • T. Iwai

      Affiliations

    • President, Tsukuba Vascular Center and Buerger Disease Research Institute
    • ,
  • Y. Izumi

      Affiliations

    • Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University
    • Center of Excellence (COE), Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University
    • ,
  • I. Ishikawa

      Affiliations

    • Center of Excellence (COE), Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University
    • Emeritus Professor, Tokyo Medical and Dental University, Visiting Professor, Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan

,Accepted 26 August 2007.

References 

  1. Dormandy JA, Rutherford RB. Management of peripheral arterial disease (PAD). TASC Working Group. TransAtlantic Inter-Society Consensus (TASC). J Vasc Surg. 2000;31(1 Pt 2):S1–S296
  2. Selvin E, Erlinger TP. Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey, 1999–2000. Circulation. 2004;110(6):738–743
  3. Signorelli SS, Mazzarino MC, Di Pino L, Malaponte G, Porto C, Pennisi G, et al. High circulating levels of cytokines (IL-6 and TNFalpha), adhesion molecules (VCAM-1 and ICAM-1) and selectins in patients with peripheral arterial disease at rest and after a treadmill test. Vasc Med. 2003;8(1):15–19
  4. Nylaende M, Kroese A, Stranden E, Morken B, Sandbaek G, Lindahl AK, et al. Markers of vascular inflammation are associated with the extent of atherosclerosis assessed as angiographic score and treadmill walking distances in patients with peripheral arterial occlusive disease. Vasc Med. 2006;11(1):21–28
  5. Page RC, Offenbacher S, Schroeder HE, Seymour GJ, Kornman KS. Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions. Periodontol 2000. 1997;14:216–248
  6. Ebersole JL, Machen RL, Steffen MJ, Willmann DE. Systemic acute-phase reactants, C-reactive protein and haptoglobin, in adult periodontitis. Clin Exp Immunol. 1997;107:347–352
  7. Loos BG, Craandijk J, Hoek FJ, Wertheim-van Dillen PM, van der Velden U. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol. 2000;71:1528–1534
  8. Dye BA, Choudhary K, Shea S, Papapanou PN. Serum antibodies to periodontal pathogens and markers of systemic inflammation. J Clin Periodontol. 2005;32:1189–1199
  9. Gorska R, Gregorek H, Kowalski J, Laskus-Perendyk A, Syczewska M, Madalinski K. Relationship between clinical parameters and cytokine profiles in inflamed gingival tissue and serum samples from patients with chronic periodontitis. J Clin Periodontol. 2003;30(12):1046–1052
  10. Haraszthy VI, Zambon JJ, Trevisan M, Zeid M, Genco RJ. Identification of periodontal pathogens in atheromatous plaques. J Periodontol. 2000;71:1554–1560
  11. Okuda K, Ishihara K, Nakagawa T, Hirayama A, Inayama Y, Okuda K. Detection of Treponema denticola in atherosclerotic lesions. J Clin Microbiol. 2001;39:1114–1117
  12. Beck J, Garcia R, Heiss G, Vokonas PS, Offenbacher S. Periodontal disease and cardiovascular disease. J Periodontol. 1996;67:1123–1137
  13. Arbes SJ, Slade GD, Beck JD. Association between extent of periodontal attachment loss and self-reported history of heart attack: an analysis of NHANES III data. J Dent Res. 1999;78:1777–1782
  14. Joshipura KJ, Hung HC, Rimm EB, Willett WC, Ascherio A. Periodontal disease, tooth loss, and incidence of ischemic stroke. Stroke. 2003;34:47–52
  15. Montebugnoli L, Servidio D, Miaton RA, Prati C, Tricoci P, Melloni C. Poor oral health is associated with coronary heart disease and elevated systemic inflammatory and haemostatic factors. J Clin Periodontol. 2004;31(1):25–29
  16. Holmlund A, Holm G, Lind L. Severity of periodontal disease and number of remaining teeth are related to the prevalence of myocardial infarction and hypertension in a study based on 4,254 subjects. J Periodontol. 2006;77(7):1173–1178
  17. Mendez MV, Scott T, LaMorte W, Vokonas P, Menzoian JO, Garcia R. An association between periodontal disease and peripheral vascular disease. Am J Surg. 1998;176(2):153–157
  18. Hung HC, Willett W, Merchant A, Rosner BA, Ascherio A, Joshipura KJ. Oral health and peripheral arterial disease. Circulation. 2003;107(8):1152–1157
  19. Kurihara N, Inoue Y, Iwai T, Umeda M, Huang Y, Ishikawa I. Detection and localization of periodontopathic bacteria in abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2004;28(5):553–558
  20. Iwai T, Inoue Y, Umeda M, Huang Y, Kurihara N, Koike M, et al. Oral bacteria in the occluded arteries of patients with Buerger disease. J Vasc Surg. 2005;42(1):107–115
  21. Chen YW, Iwai T, Umeda M, Nagasawa T, Huang Y, Takeuchi Y, et al. Elevated IgG titers to periodontal pathogens related to Buerger disease. Int J Cardiol. 2007;
  22. Beck JD, Elter JR, Heiss G, Couper D, Mauriello SM, Offenbacher S. Relationship of periodontal disease to carotid artery intima-media wall thickness: the atherosclerosis risk in communities (ARIC) study. Arterioscler Thromb Vasc Biol. 2001;21(11):1816–1822
  23. Ashimoto A, Chen C, Bakker I, Slots J. Polymerase chain reaction detection of putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions. Oral Microbiol Immunol. 1996;11:266–273
  24. Ishikawa I, Watanabe H, Horibe M, Izumi Y. Diversity of IgG antibody responses in the patients with various types of periodontitis. Adv Dent Res. 1988;2:334–338
  25. Tousoulis D, Davies G, Stefanadis C, Toutouzas P, Ambrose JA. Inflammatory and thrombotic mechanisms in coronary atherosclerosis. Heart. 2003;89(9):993–997
  26. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352(16):1685–1695
  27. Kaperonis EA, Liapis CD, Kakisis JD, Dimitroulis D, Papavassiliou VG. Inflammation and atherosclerosis. Eur J Vasc Endovasc Surg. 2006;31(4):386–393
  28. Grahame-Clarke C, Chan NN, Andrew D, Ridgway GL, Betteridge DJ, Emery V, et al. Human cytomegalovirus seropositivity is associated with impaired vascular function. Circulation. 2003;108(6):678–683
  29. Liuba P, Pesonen E, Paakkari I, Batra S, Forslid A, Kovanen P, et al. Acute Chlamydia pneumoniae infection causes coronary endothelial dysfunction in pigs. Atherosclerosis. 2003;167(2):215–222
  30. Oshima T, Ozono R, Yano Y, Oishi Y, Teragawa H, Higashi Y, et al. Association of Helicobacter pylori infection with systemic inflammation and endothelial dysfunction in healthy male subjects. J Am Coll Cardiol. 2005;45(8):1219–1222
  31. Roth GA, Moser B, Roth-Walter F, Giacona MB, Harja E, Papapanou PN, et al. Infection with a periodontal pathogen increases mononuclear cell adhesion to human aortic endothelial cells. Atherosclerosis. 2007;190:271–281
  32. Peters SR, Valdez M, Riviere G, Thomas DD. Adherence to and penetration through endothelial cells by oral treponemes. Oral Microbiol Immunol. 1999;14:379–383
  33. Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?. Atherosclerosis. 2000;148:209–214
  34. Nagasawa T, Kobayashi H, Aramaki M, Kiji M, Oda S, Izumi Y. Expression of CD14, CD16 and CD45RA on monocytes from periodontitis patients. J Periodontal Res. 2004;39:72–78

PII: S1078-5884(07)00582-5

doi: 10.1016/j.ejvs.2007.08.016

European Journal of Vascular & Endovascular Surgery
Volume 35, Issue 2 , Pages 153-158 , February 2008

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