European Journal of Vascular & Endovascular Surgery
Volume 35, Issue 4 , Pages 392-398 , April 2008

Comparison of the Inflammatory Burden of Truly Asymptomatic Carotid Atheroma with Atherosclerotic Plaques in Patients with Asymptomatic Carotid Stenosis Undergoing Coronary Artery Bypass Grafting: An Ultrasmall Superparamagnetic Iron Oxide Enhanced Magnetic Resonance Study

  • T.Y. Tang

      Affiliations

    • University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • Cambridge Vascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • ,
  • S.P.S. Howarth

      Affiliations

    • University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • Academic Department of Neurosurgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • ,
  • S.R. Miller

      Affiliations

    • Biostatistics and Data Sciences, GlaxoSmithKline, Harlow, UK
    • ,
  • M.J. Graves

      Affiliations

    • University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • ,
  • J.M. U-King-Im

      Affiliations

    • University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • ,
  • Z.Y. Li

      Affiliations

    • University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • ,
  • S.R. Walsh

      Affiliations

    • Cambridge Vascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • ,
  • P.D. Hayes

      Affiliations

    • Cambridge Vascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • ,
  • K. Varty

      Affiliations

    • Cambridge Vascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • ,
  • J.H. Gillard

      Affiliations

    • University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • Corresponding Author InformationCorresponding author. J. H. Gillard, BSc, MD, FRCR, Reader/Honorary Consultant Neuroradiologist, University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 2QQ, United Kingdom.

,Accepted 26 October 2007.

  • Image Result

    Pre (A) and post (B) USPIO imaging showing significant signal loss in the post imaging (orange arrowhead) of a patient, awaiting CABG with an asymptomatic carotid stenosis.

    Pre (A) and post (B) USPIO imaging showing significant signal loss in the post imaging (orange arrowhead) of a patient, awaiting CABG with an asymptomatic carotid stenosis.

  • Image Result

    Principles of quadrant analysis to measure normalised signal change post USPIO infusion.

    Principles of quadrant analysis to measure normalised signal change post USPIO infusion.

  • Image Result

    Comparison of percentage of quadrants showing signal loss between the two groups. Boxes show quartiles and median across patients for each group. Whiskers show minimum and maximum.

    Comparison of percentage of quadrants showing signal loss between the two groups. Boxes show quartiles and median across patients for each group. Whiskers show minimum and maximum.

  • Image Result

    USPIO-enhanced MRI signal change for 10 truly asymptomatic and 10 pre- CABG patients with an asymptomatic carotid stenosis. Boxes show quartiles and median across quadrants for each patient. Whiskers

    USPIO-enhanced MRI signal change for 10 truly asymptomatic and 10 pre- CABG patients with an asymptomatic carotid stenosis. Boxes show quartiles and median across quadrants for each patient. Whiskers show minimum and maximum. Crosses show patient means. Horizontal reference lines show group means from the repeated measures model (solid for CABG, dashed for asymptomatic).

☆ Sources of funding: GlaxoSmithKline and The Stroke Association.Disclosures: SRM is an employee of GlaxoSmithKline (GSK). JHG is a consultant to GSK.

PII: S1078-5884(07)00683-1

doi: 10.1016/j.ejvs.2007.10.019

European Journal of Vascular & Endovascular Surgery
Volume 35, Issue 4 , Pages 392-398 , April 2008

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