European Journal of Vascular & Endovascular Surgery
Volume 35, Issue 4 , Pages 392-398 , April 2008

Comparison of the Inflammatory Burden of Truly Asymptomatic Carotid Atheroma with Atherosclerotic Plaques in Patients with Asymptomatic Carotid Stenosis Undergoing Coronary Artery Bypass Grafting: An Ultrasmall Superparamagnetic Iron Oxide Enhanced Magnetic Resonance Study

  • T.Y. Tang

      Affiliations

    • University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • Cambridge Vascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • ,
  • S.P.S. Howarth

      Affiliations

    • University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • Academic Department of Neurosurgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • ,
  • S.R. Miller

      Affiliations

    • Biostatistics and Data Sciences, GlaxoSmithKline, Harlow, UK
    • ,
  • M.J. Graves

      Affiliations

    • University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • ,
  • J.M. U-King-Im

      Affiliations

    • University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • ,
  • Z.Y. Li

      Affiliations

    • University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • ,
  • S.R. Walsh

      Affiliations

    • Cambridge Vascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • ,
  • P.D. Hayes

      Affiliations

    • Cambridge Vascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • ,
  • K. Varty

      Affiliations

    • Cambridge Vascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • ,
  • J.H. Gillard

      Affiliations

    • University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • Corresponding Author InformationCorresponding author. J. H. Gillard, BSc, MD, FRCR, Reader/Honorary Consultant Neuroradiologist, University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 2QQ, United Kingdom.

,Accepted 26 October 2007.

References 

  1. Ross R. Atherosclerosis – an inflammatory disease. N Engl J Med. 1999;340(2):115–126
  2. Trivedi RA, Mallawarachi C, U-King-Im JM, Graves MJ, Horsley J, Goddard MJ, et al. Identifying inflamed carotid plaques using in vivo USPIO-enhanced MR imaging to label plaque macrophages. Arterioscler Thromb Vasc Biol. 2006;26(7):1601–1606
  3. Trivedi RA, U-King-Im JM, Graves MJ, Kirkpatrick PJ, Gillard JH. Noninvasive imaging of carotid plaque inflammation. Neurology. 2004;63(1):187–188
  4. Trivedi RA, U-King-Im JM, Graves MJ, Cross JJ, Horsley J, Goddard MJ, et al. In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI. Stroke. 2004;35(7):1631–1635
  5. Tang T, Howarth SP, Miller SR, Trivedi R, Graves MJ, King-Im JU, et al. Assessment of inflammatory burden contralateral to the symptomatic carotid stenosis using high-resolution ultrasmall, superparamagnetic iron oxide-enhanced MRI. Stroke. 2006;37(9):2266–2270
  6. Tang TY, Howarth SP, Miller SR, Graves MJ, UK-I JM, Trivedi RA, et al. Comparison of the inflammatory burden of truly asymptomatic carotid atheroma with atherosclerotic plaques contralateral to symptomatic carotid stenosis: an ultrasmall superparamagnetic iron oxide enhanced magnetic resonance study. J Neurol Neurosurg Psychiatry. 2007;
  7. U-King-Im JM, Trivedi RA, Sala E, Graves MJ, Gaskarth M, Higgins NJ, et al. Evaluation of carotid stenosis with axial high-resolution black-blood MR imaging. Eur Radiol. 2004;14(7):1154–1161
  8. Buffon A, Biasucci LM, Liuzzo G, D'Onofrio G, Crea F, Maseri A. Widespread coronary inflammation in unstable angina. N Engl J Med. 2002;347(1):5–12
  9. Spagnoli LG, Bonanno E, Mauriello A, Palmieri G, Partenzi A, Sangiorgi G, et al. Multicentric inflammation in epicardial coronary arteries of patients dying of acute myocardial infarction. J Am Coll Cardiol. 2002;40(9):1579–1588
  10. Henderson RD, Eliasziw M, Fox AJ, Rothwell PM, Barnett HJ. Angiographically defined collateral circulation and risk of stroke in patients with severe carotid artery stenosis. North American Symptomatic Carotid Endarterectomy Trial (NASCET) Group. Stroke. 2000;31(1):128–132
  11. Cohen A, Tzourio C, Bertrand B, Chauvel C, Bousser MG, Amarenco P. Aortic plaque morphology and vascular events: a follow-up study in patients with ischemic stroke. FAPS Investigators. French Study of Aortic Plaques in Stroke. Circulation. 1997;96(11):3838–3841
  12. Lombardo A, Biasucci LM, Lanza GA, Coli S, Silvestri P, Cianflone D, et al. Inflammation as a possible link between coronary and carotid plaque instability. Circulation. 2004;109(25):3158–3163
  13. Saam T, Yuan C, Chu B, Takaya N, Underhill H, Cai J, et al. Predictors of carotid atherosclerotic plaque progression as measured by noninvasive magnetic resonance imaging. Atherosclerosis. 2006;
  14. Ogren M, Hedblad B, Isacsson SO, Janzon L, Jungquist G, Lindell SE. Non-invasively detected carotid stenosis and ischaemic heart disease in men with leg arteriosclerosis. Lancet. 1993;342:1138–1141

☆ Sources of funding: GlaxoSmithKline and The Stroke Association.Disclosures: SRM is an employee of GlaxoSmithKline (GSK). JHG is a consultant to GSK.

PII: S1078-5884(07)00683-1

doi: 10.1016/j.ejvs.2007.10.019

European Journal of Vascular & Endovascular Surgery
Volume 35, Issue 4 , Pages 392-398 , April 2008

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