European Journal of Vascular & Endovascular Surgery
Volume 36, Issue 2 , Pages 125-131, August 2008

Clinical Relevance of Advanced Glycation Endproducts for Vascular Surgery

  • R. Meerwaldt

      Affiliations

    • Department of Surgery, Isala Clinics, Zwolle, The Netherlands
    • ,
  • M.G. van der Vaart

      Affiliations

    • Department of Surgery (Division of Vascular Surgery), University Medical Center Groningen, Groningen, The Netherlands
    • ,
  • G.M. van Dam

      Affiliations

    • Department of Surgery (Division of Vascular Surgery), University Medical Center Groningen, Groningen, The Netherlands
    • ,
  • R.A. Tio

      Affiliations

    • Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    • ,
  • J.-L. Hillebrands

      Affiliations

    • Department of Cell Biology (University of Groningen), University Medical Center Groningen, Groningen, The Netherlands
    • ,
  • A.J. Smit

      Affiliations

    • Department of Internal Medicine (Division of Vascular Medicine), University Medical Center Groningen, Groningen, The Netherlands
    • ,
  • C.J. Zeebregts

      Affiliations

    • Department of Surgery (Division of Vascular Surgery), University Medical Center Groningen, Groningen, The Netherlands
    • Corresponding Author InformationCorresponding author. C. J. Zeebregts, MD, PhD, Department of Surgery, Division of Vascular Surgery, University Medical Center Groningen, P.O. Box 30 001, 9700 RB Groningen, The Netherlands. Tel.: +31 503613382; fax: +31 503611745.

Received 27 November 2007; accepted 16 January 2008. published online 20 March 2008.

Abstract 

Atherosclerosis is the main contributor to cardiovascular disease and leads to intimal plaque formation, which may progress to plaque rupture with subsequent thromboembolic events and/or occlusion of the arterial lumen. There is increasing evidence that the development or progression of atherosclerosis is associated with advanced glycation endproducts (AGEs). AGEs are a heterogeneous group of compounds formed by the non-enzymatic reaction of reducing sugars with proteins, lipids, and nucleic acids. An increased understanding of the mechanisms of formation and interaction of AGEs has allowed the development of several potential anti-AGE strategies. This review summarizes AGE formation and biochemistry, the pathogeneic role of AGEs in cardiovascular disease, anti-AGE therapies and clinical relevance to vascular surgery.

Keywords: Advanced glycation, Vascular surgery, Plaque vulnerability, Patency, Diabetic foot

 

PII: S1078-5884(08)00108-1

doi:10.1016/j.ejvs.2008.01.030

European Journal of Vascular & Endovascular Surgery
Volume 36, Issue 2 , Pages 125-131, August 2008

Article Tools

* Image Usage & Resolution