European Journal of Vascular & Endovascular Surgery
Volume 36, Issue 2 , Pages 132-137 , August 2008

Increased Platelet-monocyte Aggregation in Male Claudicants with the PlA1/A2 Polymorphism of Gp IIb/IIIa

  • J. McCaslin

      Affiliations

    • Queen Elizabeth Hospital, Gateshead, UK
    • ,
  • H. Ashour

      Affiliations

    • Queen Elizabeth Hospital, Gateshead, UK
    • ,
  • V. Bhattacharya

      Affiliations

    • Queen Elizabeth Hospital, Gateshead, UK
    • ,
  • M. Cleanthis

      Affiliations

    • Northern Vascular Unit, Freeman Hospital, Newcastle-upon-Tyne, UK
    • ,
  • A. Daly

      Affiliations

    • Newcastle University, Newcastle, UK
    • ,
  • G. Stansby

      Affiliations

    • Northern Vascular Unit, Freeman Hospital, Newcastle-upon-Tyne, UK
    • Corresponding Author InformationCorresponding author. Prof G. Stansby, Northern Vascular Unit, Freeman Hospital, Newcastle-upon-Tyne NE7 7DN, UK. Tel.: +191 2231125; fax: +191 2231489.

Received 31 October 2007 ,Accepted 15 February 2008.

  • Image Result

    Platelet Monocyte Aggregation in PlA1 versus PlA2. Mann-Whitney test shows a trend towards higher binding in PlA2 genotype but is not significant (p=0.17) in both sexes combined (left). PMA formation

    Platelet Monocyte Aggregation in PlA1 versus PlA2. Mann-Whitney test shows a trend towards higher binding in PlA2 genotype but is not significant (p=0.17) in both sexes combined (left). PMA formation by genotype in males only is significant (p=0.019) (right).

  • Image Result
    Aspirin resistance as defined by PMA formation above the mean aggregation of 12.5%. Significantly more patients with the PlA2 allele are found in the aspirin resistant group (p=0.0418, Chi-squared tes

    Aspirin resistance as defined by PMA formation above the mean aggregation of 12.5%. Significantly more patients with the PlA2 allele are found in the aspirin resistant group (p=0.0418, Chi-squared test). This association is stronger in the males (p=0.0101) but not evident in the females (p=0.9282).

PII: S1078-5884(08)00155-X

doi: 10.1016/j.ejvs.2008.02.016

European Journal of Vascular & Endovascular Surgery
Volume 36, Issue 2 , Pages 132-137 , August 2008

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