European Journal of Vascular & Endovascular Surgery
Volume 36, Issue 3 , Pages 346-352 , September 2008

Significance of Phlebosclerosis in Non-healing Ischaemic Foot Ulcers of End-stage Renal Disease

  • H. Yasuhara

      Affiliations

    • Surgical Centre, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • Corresponding Author InformationCorresponding author. Tel./fax: +81 3 5800 8735.
  • ,
  • T. Hattori

      Affiliations

    • Department of Cardiovascular Surgery, Teikyo University Ichihara Hospital, Chiba 299-0111, Japan
  • ,
  • O. Shigeta

      Affiliations

    • Department of Cardiovascular Surgery, Teikyo University Ichihara Hospital, Chiba 299-0111, Japan

Received 26 December 2007 ,Accepted 11 May 2008.

References 

  1. Johnson BL, Glickman MH, Bandyk DF, Esses GE. Failure of foot salvage in patients with end-stage renal disease after surgical revascularization. J Vasc Surg. 1995;22:280–285
  2. Peltonen S, Biancari F, Lindgren L, Makisalo H, Honkanen E, Lepantalo M. Outcome of infrainguinal bypass surgery for critical leg ischaemia in patients with chronic renal failure. Eur J Vasc Endovasc Surg. 1998;15:122–127
  3. Arora S, Pomposelli F, LoGerfo FW, Veves A. Cutaneous microcirculation in the neuropathic diabetic foot improves significantly but not completely after successful lower extremity revascularization. J Vasc Surg. 2002;35:501–505
  4. Yildiz A, Memisoglu E, Oflaz H, Yazici H, Pusuroglu H, Akkaya V, et al. Atherosclerosis and vascular calcification are independent predictors of left ventricular hypertrophy in chronic haemodialysis patients. Nephrol Dial Transplant. 2005;20:760–767
  5. Ngo BT, Hayes KD, DiMiao DJ, Srinivasan SK, Huerter CJ, Rendell MS. Manifestations of cutaneous diabetic microangiopathy. Am J Clin Dermatol. 2005;6:225–237
  6. Wigington G, Ngo B, Rendell M. Skin blood flow in diabetic dermopathy. Arch Dermatol. 2004;140:1248–1250
  7. Stewart J, Kohen A, Brouder D, Rahim F, Adler S, Garrick R, et al. Noninvasive interrogation of microvasculature for signs of endothelial dysfunction in patients with chronic renal failure. Am J Physiol Heart Circ Physiol. 2004;287:H2687–H2696
  8. Hinchliffe RJ, Kirk B, Bhattacharjee D, Roe S, Jeffcoate W, Game F. The effect of haemodialysis on transcutaneous oxygen tension in patients with diabetes – a pilot study. Nephrol Dial Transplant. 2006;21:1981–1983
  9. Bouisson H, Escouron G, Julian M, Pieraggi MT. Hypothesis on microangiopathy of cutaneous capillaries. Atherosclerosis. 1978;29:397–403
  10. Fahrig C, Breitinger L, Heidrich H. Vital capillary microscopic findings in the nailfold of patients with diabetes mellitus. Vasa. 2000;29:258–263
  11. Piaqqesi A, Viacava P, Rizzo L, Naccarato G, Baccetti F, Romanelli M, et al. Semiquantitative analysis of the histopathological features of the neuropathic foot ulcer: effects of pressure relief. Diabetes Care. 2003;26:3123–3128
  12. Veves A, Akbari CM, Primavera J, Donaqhue VM, Sacharoulis D, Chrzan JS, et al. Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease, and foot ulceration. Diabetes. 1998;47:457–463
  13. Pascarella L, Schmid-Schonbein GW, Bergan J. An animal model of venous hypertension: the role of inflammation in venous valve failure. J Vasc Surg. 2005;41:203–211
  14. Anvar MD, Khiabani HZ, Nesland JM, Stranden E, Kroese AJ. Vascular and stromal features in the skin of the lower limb in patients with chronic critical limb ischaemia (CLI) and Oedema. Eur J Vasc Endovasc Surg. 2000;20:125–131
  15. Coats P. Myogenic, mechanical and structural characteristics of resistance arterioles from healthy and ischaemic subjects. Clin Sci (Lond). 2003;105:683–689
  16. Pascarella L, Penn A, Schmid-Schonbein GW. Venous hypertension and the inflammatory cascade: major manifestations and trigger mechanisms. Angiology. 2005;56(Suppl. 1):S3–S10
  17. Leu HJ. Morphology of chronic venous insufficiency – light and electron microscopic examinations. Vasa. 1991;20:330–342
  18. Bollinger A, Leu AJ, Hoffmann U, Franzeck UK. Microvascular changes in venous disease: an update. Angiology. 1997;48:27–32
  19. Poulaki V, Qin W, Joussen AM, Hurlbut P, Wieqand SJ, Rudge J, et al. Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1 alpha and VEGF. J Clin Invest. 2002;109:805–815
  20. van Veen S, Chang PC. Modulation of vasoconstriction by insulin. J Hypertens. 1998;16:1157–1164
  21. Scheinowitz M, Abramov D, Eldar M. The role of insulin-like and basic fibroblast growth factors on ischaemic and infarcted myocardium: a mini review. Int J Cardiol. 1997;59:1–5
  22. Ajjam ZS, Barton S, Corbett M, Owens D, Marks R. Quantitative evaluation of the dermal vasculature of diabetics. Q J Med. 1985;54:229–239

 Source of finance: None.

PII: S1078-5884(08)00269-4

doi: 10.1016/j.ejvs.2008.05.003

European Journal of Vascular & Endovascular Surgery
Volume 36, Issue 3 , Pages 346-352 , September 2008