European Journal of Vascular & Endovascular Surgery
Volume 39, Issue 3 , Pages 295-301 , March 2010

High Levels of 18F-FDG Uptake in Aortic Aneurysm Wall are Associated with High Wall Stress

  • X.Y. Xu

      Affiliations

    • Department of Chemical Engineering, Imperial College London, UK
    • ,
  • A. Borghi

      Affiliations

    • Department of Chemical Engineering, Imperial College London, UK
    • ,
  • A. Nchimi

      Affiliations

    • Department of Radiology, CHC, Liege, Belgium
    • ,
  • J. Leung

      Affiliations

    • Department of Chemical Engineering, Imperial College London, UK
    • ,
  • P. Gomez

      Affiliations

    • Department of Nuclear Medicine, CHC, Liege, Belgium
    • ,
  • Z. Cheng

      Affiliations

    • Department of Chemical Engineering, Imperial College London, UK
    • ,
  • J.O. Defraigne

      Affiliations

    • Department of Cardiovascular Surgery, University Hospital of Liege, Liege, Belgium
    • ,
  • N. Sakalihasan

      Affiliations

    • Department of Cardiovascular Surgery, University Hospital of Liege, Liege, Belgium
    • Corresponding Author InformationCorresponding author. Tel.: +32 436 67163; fax: +32 4366 7164.

Received 28 June 2009 ,Accepted 20 October 2009.

References 

  1. Sakalihasan N, Limet R, Defawe OD. Abdominal aortic aneurysm. Lancet. 2005;365(9470):1577–1589
  2. Brewster DC, Cronenwett JL, Hallett JW, Johnston KW, Krupski WC, Matsumura JS. Guidelines for the treatment of abdominal aortic aneurysms. Report of a subcommittee of the Joint Council of the American Association for Vascular Surgery and Society for Vascular Surgery. J Vasc Surg. 2003;37:1106–1117
  3. Sakalihasan N, Van Damme H, Gomez P, Rigo P, Lapiere CM, Nusgens B, et al. Positron emission tomography (PET) evaluation of abdominal aortic aneurysm (AAA). Eur J Vasc Endovasc Surg. 2002;23:431–436
  4. Defawe OD, Hustinx R, Defraigne JO, Limet R, Sakalihasan N. Distribution of F-18 fluorodeoxyglucose (F-18 FDG) in abdominal aortic aneurysm: high accumulation in macrophages seen on PET imaging and immunohistology. Clin Nucl Med. 2005 May;30(5):340–341
  5. Reeps Ch, Essler M, Pelisek J, Seidl S, Eckstein HH, Krause BJ. Increased 18F-fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic wall instability, and acute symptoms. J Vasc Surg. 2008;48(2):417–423
  6. Truijers M, Kurvers HA, Bredie SJ, Oyen WJ, Blankensteijn JD. In vivo imaging of abdominal aortic aneurysms; increased FDG uptake suggests inflammation in the aneurysmal wall. J Endovasc Ther. 2008;15(4):462–467
  7. Thubrikar MJ, Al-Soudi J, Robicsek F. Wall stress studies of the abdominal aortic aneurysm in a clinical model. Ann Vasc Surg. 2001;15:355–366
  8. Venkatasubramaniam AK, Fagan MJ, Mehta T, Mylankal KJ, Ray B, Kuhan G, et al. A comparative study of aortic wall stress using finite element analysis for ruptured and non-ruptured abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2004;28:168–176
  9. Fillinger MF, Marra SP, Raghavan ML, Kennedy FE. Prediction of rupture risk in abdominal aortic aneurysm during observation: wall stress versus diameter. J Vasc Surg. 2003;37:724–732
  10. Fillinger MF, Raghavan ML, Marra SP, Cronenwett JL, Kennedy FE. In vivo analysis of mechanical wall stress and abdominal aortic aneurysm rupture risk. J Vasc Surg. 2002;36:589–597
  11. Burger C, Goerres G, Schoenes S, Buck A, Lonn AHR, von Schultess GK. PET attenuation coefficients from CT images: experimental evaluation of the transformation of CT into PET 511-keV attenuation coefficients. Eur J Nucl Med. 2002;29:922–927
  12. Leung JH. Determination of flow patterns and stresses in patient-specific models of abdominal aortic aneurysm. PhD thesis, Imperial College London;2006.
  13. Leung JH, Wright AR, Cheshire N, Crane J, Thom SA, Hughes AD, et al. Fluid structure interaction of patient specific abdominal aortic aneurysms: a comparison with solid stress models. BioMed Eng Online. 2006;5:33
  14. Gonzalez RC, Woods RE. Digital image processing. Upper Saddle River, New Jersey: Prentice-Hall Inc; 2002;
  15. Raghavan ML, Vorp DA. Toward a biomechanical tool to evaluate rupture potential of abdominal aortic aneurysm: identification of a finite strain constitutive model and evaluation of its applicability. J Biomech. 2000;33:475–482
  16. Wang DH, Makaroun M, Webster MW, Vorp DA. Mechanical properties and microstructure of intraluminal thrombus from abdominal aortic aneurysm. J Biomech Eng. 2001;123:536–539
  17. Tawakol A, Migrino RQ. Noninvasive in vivo measurement of vascular inflammation with F-18 fluorodeoxyglucose positron emission tomography. J Nucl Cardiol. 2005;12:294–301

PII: S1078-5884(09)00553-X

doi: 10.1016/j.ejvs.2009.10.016

European Journal of Vascular & Endovascular Surgery
Volume 39, Issue 3 , Pages 295-301 , March 2010

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