European Journal of Vascular & Endovascular Surgery
Volume 39, Issue 6 , Pages 779-786 , June 2010

Ultrasound-Guided Sclerotherapy of the Great Saphenous Vein with 1% vs. 3% Polidocanol Foam: A Multicentre Double-Blind Randomised Trial with 3-Year Follow-Up

  • S. Blaise

      Affiliations

    • Department of Vascular Medicine, Grenoble University Hospital, France
    • ,
  • J.L. Bosson

      Affiliations

    • CIC-INSERM, Grenoble University Hospital, Grenoble, France
    • Corresponding Author InformationCorresponding author. Tel.: +33 4 76 76 53 61; fax: +33 4 76 76 50 48.
    • ,
  • J.M. Diamand

      Affiliations

    • Rhone-Alpes Association of Private Vascular Physician, Grenoble, France

Received 14 May 2009 ,Accepted 9 January 2010.

References 

  1. Hamel-Desnos C, Ouvry P, Benigni J-P, Boitelle G, Schadeck M, Desnos P, et al. Comparison of 1% and 3% polidocanol foam in ultrasound guided sclerotherapy of the great saphenous vein: a randomized double-blind trial with 2 year-follow-up. “The 3/1 study”. Eur J Vasc Endovasc Surg. 2007;34:723–729
  2. Rutherford RB, Padberg FT, Comerota AJ, Kistner RL, Meissner MH, Moneta GL. Venous severity scoring: an adjunct to venous outcome assessment. J Vasc Surg. 2000;31:1307–1312
  3. Launois R, Reboul-Marty J, Henry B. Construction and validation of a quality of life questionnaire in chronic lower limb venous insufficiency (CIVIQ). Qual Life Res. 1996;5:539–554
  4. Rabe E, Otto J, Schliephake D, Pannier F. Efficacy and safety of great saphenous vein sclerotherapy using standardized polidocanol foam (ESAF): a randomized controlled multicentre clinical trial. Eur J Vasc Endovasc Surg. 2007;35:238–245
  5. Alos J, Carreno P, Lopez JA, Estadella B, Serrat-Prat M, Marinel-Lo J. Efficacy and safety of sclerotherapy polidocanol foam: a controlled clinical trial. Eur J Vasc Endovasc Surg. 2006;31:101–107
  6. Hamel-Desnos C, Desnos P, Wollmann JC, Ouvry P, Mako S, Allaert FA. Evaluation of the efficacy of polidocanol in the form of foam compared with liquid form in sclerotherapy of the greater saphenous vein: initial results. Dermatol Surg. 2003;29(12):1170–1175
  7. Ouvry P, Allaert FA, Desnos P, Hamel-Desnos C. Efficacy of polidocanol foam versus liquid in sclerotherapy of the great saphenous vein: a multicentre randomised controlled trial with a 2 year follow-up. Eur J Vasc Endovasc Surg. 2008;36:366–370
  8. Jia X, Mowatt G, Burr JM, Cassar K, Cook J, Fraser C. Systematic review of foam sclerotherapy for varicose veins. Br J Surg. 2007;94:925–936
  9. Wright D, Gobin JP, Bradbury AW, Coleridge-Smith P, Spoelstra H, Berridge D, et al. Varisolve® polidocanol microfoam compared with surgery or sclerotherapy in the management of varicose veins in the presence of trunk vein incompetence: European randomized controlled trial. Phlebology. 2006;21:180–190
  10. Rao J, Goldman MP. Stability of foam in sclerotherapy: differences between sodium tetradecyl sulfate and polidocanol and the type of connector used in the double-syringe system technique. Dermatol Surg. 2005 Jan;31(1):19–22
  11. Hamel-Desnos C, Desnos P. L'écho-sclérothérapie à la mousse en 2004. Technique de la ponction-injection directe. Phlébologie. 2004;57:289–300
  12. Barrett JM, Allen B, Ockelford A, Goldman MP. Microfoam ultrasound-guided sclerotherapy treatment for varicose veins in a subgroup with diameters at the junction of 10 mm or greater compared with a subgroup of less than 10 mm. Dermato Surg. 2004;30:1386–1390
  13. Hamel-Desnos C, Allaert FA, Benigni J-P, Boitelle G, Chleir F, Ouvry P, et al. Etude 3/1.Mousse de Polidocanol 3% versus 1% dans la grande veine saphène: premiers résultats. Phlébologie. 2005;58:165–173
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  15. Breu FX, Guggenbichler S. European consensus meeting on foam sclerotherapy, April, 4–6, 2003, Tegernsee, Germany. Dermatol Surg. 2004;30:709–717
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  17. Ceulen RPM, Bullens-Goessens YIJM, Pi-Van De Venne SJA, Nelemans PJ, Veraart JCJM, Sommer A. Outcomes and side effects of duplex-guided sclerotherapy in the treatment of great saphenous veins with 1% versus 3% polidocanol foam: results of a randomized controlled trial with 1-Year follow-up. Dermatol Surg. 2007;33:276–281
  18. Barrett JM, Allen B, Ockelford A, Goldman MP. Microfoam ultrasound-guided sclerotherapy of varicose veins in 100 legs. Dermatol Surg. 2004;30:6–12
  19. Myers KA, Jolley D. Factors affecting the risk of deep venous occlusion after ultrasound-guided sclerotherapy for varicose veins. Eur J Vasc Endovasc Surg. 2008;36(5):602–605
  20. Guex JJ, Allaert FA, Gillet JL, Chleir F. Immediate and midterm complications of sclerotherapy: report of a prospective multicenter registry of 12,173 sclerotherapy sessions. Dermatol Surg. 2005;31(2):123–128
  21. Myers KA, Jolley D, Clough A, Kirwan J. Outcome of ultrasound-guided sclerotherapy for varicose veins: medium-term results assessed by ultrasound surveillance. Eur J Vasc Endovasc Surg. 2007;33(1):116–121

PII: S1078-5884(10)00058-4

doi: 10.1016/j.ejvs.2010.01.022

European Journal of Vascular & Endovascular Surgery
Volume 39, Issue 6 , Pages 779-786 , June 2010

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