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Are There Additional Benefits of Blood Pressure Control in Patients with Abdominal Aortic Aneurysm Besides Cardiovascular Risk Reduction?

  • Anders Gottsäter
    Correspondence
    Corresponding author. Department of Internal Medicine, Clinical Research Unit, Lund University, Skåne University Hospital, S-205 02 Malmö, Sweden.
    Affiliations
    Department of Internal Medicine, Clinical Research Unit, and Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden
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  • Peter M. Nilsson
    Affiliations
    Department of Internal Medicine, Clinical Research Unit, and Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden
    Search for articles by this author
      In this issue,
      • Singh T.P.
      • Moxon J.V.
      • Gasser T.C.
      • Dalman R.L.
      • Bourke M.
      • Bourke B.
      • et al.
      Effect of telmisartan on the peak wall stress of small abdominal aortic aneurysms: An exploratory analysis of the TEDY trial.
      Singh et al. report on the effects of the angiotensin 1 receptor blocker telmisartan in reducing abdominal aortic aneurysm (AAA) peak wall stress (PWS) and the peak wall rupture index (PWRI) in a subgroup of patients with small AAAs from the Telmisartan in the Management of Abdominal Aortic Aneurysm (TEDY) trial. In this randomised study, no effects upon AAA growth with telmisartan were demonstrated in spite of mechanisms linked to vascular protection associated with telmisartan, for example improvement of arterial remodelling, anti-oxidation, and antifibrotic effects in an animal model.
      • Shang P.
      • Liu T.
      • Liu W.
      • Li Y.
      • Dou F.
      • Zhang Y.
      • et al.
      Telmisartan improves vascular remodeling through ameliorating prooxidant and profibrotic mechanisms in hypertension via the involvement of transforming growth factor-β1.
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      References

        • Singh T.P.
        • Moxon J.V.
        • Gasser T.C.
        • Dalman R.L.
        • Bourke M.
        • Bourke B.
        • et al.
        Effect of telmisartan on the peak wall stress of small abdominal aortic aneurysms: An exploratory analysis of the TEDY trial.
        Eur J Vasc Endovasc Surg. 2022; 64: 396-404
        • Shang P.
        • Liu T.
        • Liu W.
        • Li Y.
        • Dou F.
        • Zhang Y.
        • et al.
        Telmisartan improves vascular remodeling through ameliorating prooxidant and profibrotic mechanisms in hypertension via the involvement of transforming growth factor-β1.
        Mol Med Rep. 2017; 16: 4537-4544
        • Wanhainen A.
        • Hultgren R.
        • Linné A.
        • Holst J.
        • Gottsäter A.
        • Langenskiöld M.
        • et al.
        Swedish Aneurysm Screening Study group (SASS). Outcome of the Swedish nationwide abdominal aortic aneurysm screening program.
        Circulation. 2016; 134: 1141-1148
        • Wanhainen A.
        • Fabio Verzini F.
        • Van Herzeele I.
        • Allaire E.
        • Bown M.
        • Cohnert T.
        • et al.
        Editor’s Choice – European Society for Vascular Surgery (ESVS) 2019 Clinical practice guidelines on the management of abdominal aorto-iliac artery aneurysms.
        Eur J Vasc Endovasc Surg. 2019; 57: 8-93
        • Zarrouk M.
        • Holst J.
        • Lundqvist A.
        • Troëng T.
        • Gottsäter A.
        Cost-effectiveness of screening for abdominal aortic aneurysm in combination with medical intervention in patients with small aneurysms.
        Eur J Vasc Endovasc Surg. 2016; 51: 766-773
        • Bahia S.S.
        • Vidal-Diez A.
        • Seshasai S.R.
        • Shpitser I.
        • Brownrigg J.R.
        • Patterson B.O.
        • et al.
        Cardiovascular risk prevention and all-cause mortality in primary care patients with an abdominal aortic aneurysm.
        Br J Surg. 2016; 103: 1626-1633

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