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Molecular Imaging of Experimental Abdominal Aortic Aneurysms Targeting Vascular Homeostasis Disruption via CD31 Shedding

Published:October 06, 2022DOI:https://doi.org/10.1016/j.ejvs.2022.10.004
      CD31 is a constitutive regulatory receptor that has crucial functions in the maintenance of homeostasis at the blood–vessel interface. Its loss at the surface (shedding) of both circulating and aneurysm infiltrated immune cells is a characteristic feature of patients presenting with abdominal aortic aneurysms (AAAs).
      • Caligiuri G.
      • Rossignol P.
      • Julia P.
      • Groyer E.
      • Mouradian D.
      • Urbain D.
      • et al.
      Reduced immunoregulatory CD31+ T cells in patients with atherosclerotic abdominal aortic aneurysm.
      The use of a novel radiolabelled peptide targeting CD31shed cells (P8RI; a synthetic CD31 agonist) at sites of active tissue inflammation has previously been developed and validated.
      • Vigne J.
      • Bay S.
      • Aid-Launais R.
      • Pariscoat G.
      • Rucher G.
      • Senemaud J.
      • et al.
      Cleaved CD31 as a target for in vivo molecular imaging of inflammation.
      The present study sought to identify the presence of active inflammatory loci in an experimental animal model of progressive AAAs using single photon emission computed tomography (SPECT) imaging and Tc99m labelled D-P8RI.

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