Publication stageIn Press Accepted Manuscript
☆WHAT THIS PAPER ADDS: Liproprotein lipase (LPL) has been independently associated with primary acute myocardial infarction and coronary artery disease. The current study shows that LPL is also associated with secondary major adverse cardiovascular events. In addition to this, LPL was found to have varying hazard at different time point following carotid endarterectomy (CEA), which has not been described before. Moreover, this study demonstrated that higher LPL levels are associated with a more favourable plaque composition consisting of smaller lipid core and less macrophage burden. LPL is currently of particular interest due to possible new therapy strategies that target LPL activity via angiopoietin-like 3, angiopoietin-like 4, or apolipoprotein C3 (APOC3) to reduce the risk of cardiovascular disease.
User licenseCreative Commons Attribution (CC BY 4.0) |
- Read, print & download
- Redistribute or republish the final article
- Text & data mine
- Translate the article
- Reuse portions or extracts from the article in other works
- Sell or re-use for commercial purposes
Elsevier's open access license policy
ScienceDirectAccess this article on ScienceDirect
To submit a comment for a journal article, please use the space above and note the following:
- We will review submitted comments as soon as possible, striving for within two business days.
- This forum is intended for constructive dialogue. Comments that are commercial or promotional in nature, pertain to specific medical cases, are not relevant to the article for which they have been submitted, or are otherwise inappropriate will not be posted.
- We require that commenters identify themselves with names and affiliations.
- Comments must be in compliance with our Terms & Conditions.
- Comments are not peer-reviewed.